Long term side effects of lamictal - Sep 23, 2022 · Warning. Suicidality Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. b c d Venlafaxine is not approved for use in pediatric patients. 1 3 (See Pediatric Use under Cautions.)

 
Basics Side effects Lamictal rash Common questions Dosage What to consider Uses Withdrawal Overdose How to take Cost Resources and support Q&A Lamictal basics If you have bipolar disorder,.... Crowd tracker knott

Oct 4, 2016 · That said, the side effects associated with lamotrigine may be more tolerable than side effects induced by other anxiolytic medications. As was already mentioned, lamotrigine does not appear to impair cognitive function and may even provide a modest boost in cognition. Additionally, long-term trials suggest that lamotrigine is a “weight ... Very common side effects of taking lamotrigine (affecting more than one in ten people) include: headaches; skin rashes; Common side effects of taking lamotrigine (affecting up to one in ten people) include: feeling aggressive, agitated or irritable; feeling sleepy, tired or drowsy; insomnia (having difficulty sleeping) feeling dizzy; shaking or ... Sep 23, 2022 · Warning. Suicidality Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. b c d Venlafaxine is not approved for use in pediatric patients. 1 3 (See Pediatric Use under Cautions.) Precautions Talk with your doctor Lamictal (lamotrigine) is a brand-name drug that’s prescribed for bipolar disorder and epilepsy. As with other drugs, Lamictal can cause side effects....The safety of using Lamictal during pregnancy has not been established. Lamictal is secreted into breast milk, and breastfeeding while taking Lamictal is not recommended. Our Lamictal Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.Lamictal (lamotrigine) is a mood stabilizer and anticonvulsant prescribed to treat bipolar disorder and epilepsy. This medication can be used to reduce the occurrence of mood episodes in people with bipolar disorder and to control seizures in people with epilepsy. If people suddenly stop taking their medication, they may experience Lamictal ...Aug 11, 2023 · multiple swollen and inflamed skin lesions. muscle pain or stiffness. muscle tension or tightness. normal menstrual bleeding occurring earlier, possibly lasting longer than expected. numbness of the feet, hands and around mouth. pains in the stomach, side, or abdomen, possibly radiating to the back. It’s used for long-term treatment of the more severe type of bipolar disorder, ... The more common side effects of Lamictal in people treated for bipolar I disorder include: nausea;Jun 1, 2023 · Blistering, peeling, or loosening of the skin chills cough dark urine diarrhea fever general feeling of discomfort or illness headache itching joint pain loss of appetite memory loss muscle cramps, pain, or weakness red or irritated eyes runny nose shivering small red or purple spots on the skin ... For Healthcare Professionals General. The more commonly reported adverse reactions have included dizziness, headache, diplopia, ataxia, nausea,... Immunologic. In cases of hemophagocytic lymphohistiocytosis (HLH), patients have presented with signs of systemic... Hypersensitivity. Nervous system. ...Jun 1, 2023 · Blistering, peeling, or loosening of the skin chills cough dark urine diarrhea fever general feeling of discomfort or illness headache itching joint pain loss of appetite memory loss muscle cramps, pain, or weakness red or irritated eyes runny nose shivering small red or purple spots on the skin ... I have been on Lamictal for a long time now and it helps me greatly. It had some side effects in the beginning tho. Increase in sexdrive, appetite fluxtuation, insomnia, and mild dehydration were mine. Every drug effects everybody differently tho. I haven't had any long term side effects from this drug.Jul 27, 2023 · Precautions Talk with your doctor Lamictal (lamotrigine) is a brand-name drug that’s prescribed for bipolar disorder and epilepsy. As with other drugs, Lamictal can cause side effects.... In long-term studies of at least 48-weeks in adults, increased from baseline in mean fasting cholesterol, LDL, triglycerides were 5.6 mg/dL, 2.5 mg/dL, and 18.7 mg/dL, respectively. Mean increases in fasting lipid values (total cholesterol, LDL and triglycerides) were greater in patients without evidence of lipid dysregulation at baseline.Serious side effects; Other side effects; Professional info; FAQ; Applies to nystatin: oral suspension, oral tablet. Serious side effects of Nystatin. Along with its needed effects, nystatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Other side effects of ...Lamotrigine (LTG) is a drug commonly used to treat epilepsy and can also be used to manage mood disorders, such as bipolar disorder. One of the most dangerous adverse effects of LTG is skin rash, which can make early cessation necessary. Here, we examine the adverse effects associated with long-term use of LTG for the treatment of mood disorders.I have been on Lamictal for a long time now and it helps me greatly. It had some side effects in the beginning tho. Increase in sexdrive, appetite fluxtuation, insomnia, and mild dehydration were mine. Every drug effects everybody differently tho. I haven't had any long term side effects from this drug. Other side effects include: infection, dyspepsia, abnormal gait, constipation, and drowsiness. Continue reading for a comprehensive list of adverse effects. Applies to lamotrigine: oral tablets conventional, oral tablets extended-release film-coated, oral tablets for oral suspension, oral tablets orally disintegrating.Lastly, we discuss the evidence on lithium's proposed suicide-preventive effects, the dangers of rapid discontinuation and lithium's adverse effects, particularly with regard to long-term treatment. Lithium has been the treatment of choice for patients with bipolar disorder (BD) for nearly 70 years.Geriatric Although appropriate studies on the relationship of age to the effects of lamotrigine have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of lamotrigine in the elderly. Blistering, peeling, or loosening of the skin chills cough dark urine diarrhea fever general feeling of discomfort or illness headache itching joint pain loss of appetite memory loss muscle cramps, pain, or weakness red or irritated eyes runny nose shivering small red or purple spots on the skin ...I have been on Lamictal for a long time now and it helps me greatly. It had some side effects in the beginning tho. Increase in sexdrive, appetite fluxtuation, insomnia, and mild dehydration were mine. Every drug effects everybody differently tho. I haven't had any long term side effects from this drug. For Healthcare Professionals General. The more commonly reported adverse reactions have included dizziness, headache, diplopia, ataxia, nausea,... Immunologic. In cases of hemophagocytic lymphohistiocytosis (HLH), patients have presented with signs of systemic... Hypersensitivity. Nervous system. ...Geriatric Although appropriate studies on the relationship of age to the effects of lamotrigine have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of lamotrigine in the elderly.At first I was just on abilify— a pretty high dose— and while it kept me free from hypomania, it didn’t really do much for the depression. Lamictal, on the other hand, has worked wonders in that respect. Very little side effects— I wake up nauseous but it fades after about an hour, and it’s definitely worth it. stomach pain and cramps. swelling of the face, fingers, feet, or lower legs. trouble breathing. twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs. unpleasant breath odor. vomiting of blood. watery or bloody diarrhea. weight gain. yellow eyes or skin.Long-term side effects of Lamictal abuse can include an increased incidence of drug dependence and likelihood for addiction. Misusing Lamictal increases the likelihood of experiencing all of the potential side effects. Spotting Lamictal Addiction. Addiction is a complex condition.Rarely, lurasidone can cause deadly symptoms. NMS can affect your heart, muscles, and kidneys. See your doctor right away if you get: A high fever. Stiff muscles. A change in your mood or behavior ... Apr 12, 2023 · Lamictal (lamotrigine) is a mood stabilizer and anticonvulsant prescribed to treat bipolar disorder and epilepsy. This medication can be used to reduce the occurrence of mood episodes in people with bipolar disorder and to control seizures in people with epilepsy. If people suddenly stop taking their medication, they may experience Lamictal ... In 2 longer-term trials, the mean change in blood glucose from baseline in patients treated with this drug (mean exposure 213 days; n=646) was 5 mg/dL (vs. placebo -0.05 mg/dL). Among patients with major depressive disorder receiving the extended-release formulation of this drug, a FBG greater than 126 mg/dL occurred in 7%, 12%, and 6% of those ...The phase IV clinical study analyzes which people take Lamotrigine and have Brain damage. It is created by eHealthMe based on reports of 61,601 people who have side effects when taking Lamotrigine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions. Phase IV trials are used to detect ...Hi, I have been on Lamictal 300mg for about 4 years. My loss of memory and inability to pull out words has gotten to the point where I'm not enjoying life. Holding a conversation that lasts a few sentences has become embarassing. I was wondering if anyone who has been on lamictal and taken off has had their memory return. I will talk to my doctor but the last time I went in they tried to ...Although ophthalmological testing was performed in 1 controlled clinical trial, the testing was inadequate to exclude subtle effects or injury occurring after long-term exposure. Moreover, the capacity of available tests to detect potentially adverse consequences, if any, of lamotrigine’s binding to melanin is unknown [see Clinical ... lamotrigine (Lamictal); lithium (Eskalith, Eskalith CR, Lithobid) ... The body can develop dependence if used long term. Side effects. Side effects of stimulants include: problems with sleep; poor ...Lamictal (lamotrigine) is a mood stabilizer and anticonvulsant prescribed to treat bipolar disorder and epilepsy. This medication can be used to reduce the occurrence of mood episodes in people with bipolar disorder and to control seizures in people with epilepsy. If people suddenly stop taking their medication, they may experience Lamictal ...Adverse effects. Lamotrigine’s adverse effect profile is similar to placebo in all categories except sleep disruption. 1 This often presents as vivid dreams and can be minimized by dosing in the morning and using behavioral methods to deepen sleep. Other adverse effects usually improve with dose reduction. Difficulties in swallowing the ...May 20, 2022 · Many people can take lamotrigine safely for several months or years. But there are some side effects that might happen over a long time. Long-term treatment with lamotrigine can cause osteoporosis and osteopenia, increasing your risk of breaking a bone. Your doctor can arrange for tests to check your bone strength. Aug 1, 2023 · dryness of the mouth. feeling of warmth and redness of the face, neck, arms, and occasionally chest. heartburn. increased sweating. increased urination. itching of the vagina. trouble sleeping. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Common (1% to 10%): Arthralgia, blood creatinine phosphokinase increased/creatine phosphokinase increased, muscle rigidity, muscle spasms, muscle twitching, musculoskeletal stiffness, myalgia, pain in extremity. Uncommon (0.1% to 1%): Mobility decreased, muscle tightness, muscular weakness, musculoskeletal rigidity.dryness of the mouth. feeling of warmth and redness of the face, neck, arms, and occasionally chest. heartburn. increased sweating. increased urination. itching of the vagina. trouble sleeping. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.Traditional AEDs such as valproate and enzyme-inducing AEDs (EIAEDs) may produce high incidences of decreased libido. Recently, sexual function changes related to new AEDs have been reported. Topiramate, pregabalin and gabapentin may cause SD, whereas oxcarbazepine, lamotrigine and levetiracetam may improve sexual function. But Lamictal does give me low red blood cell counts, for which I take a B12 supplement. If Lamictal (or some other cause) has led to a B12 deficiency, that could explain a number of your symptoms. A B12 deficiency can cause: --weakness, tiredness or light-headedness. --rapid heartbeat and breathing.Lamictal Tablet. - Uses, Side Effects, and More. Warnings: Rarely, serious (sometimes fatal) skin rashes have occurred while taking this medication. These rashes are more common in children than ...Mar 20, 2017 · Results. Treatment efficacy was observed at week 4, with the improved HSDS scores sustained until week 52 for all types of BP; 50% of the patients with any type of BP could be treated with LTG for 1 year, whereas ~40% could be treated for >1.5 years. However, 25% of the patients were withdrawn within the first 4 weeks. For example, it is known that side effects like: ataxia, blurred vision, double vision, dizziness, nausea, and vomiting – are substantially more likely to occur among persons taking Lamictal at dosages of 500 mg per day – compared to persons taking Lamictal at dosages of 300 mg per day.Definitely a very bad side effect was the degeneration of my teeth, my dentist implied it was quite common, a marked improvement since I stopped taking them in 2018. It does not seem to be listed there. My general bone density is poor after many seizures over the years, especially my rib cage and skull, I have reached a limit one more seizure ...Jun 1, 2023 · Blistering, peeling, or loosening of the skin chills cough dark urine diarrhea fever general feeling of discomfort or illness headache itching joint pain loss of appetite memory loss muscle cramps, pain, or weakness red or irritated eyes runny nose shivering small red or purple spots on the skin ... redness of the face, neck, arms and occasionally, upper chest. shakiness and unsteady walk. sudden death. trouble concentrating. trouble sleeping. unconsciousness. unsteadiness, trembling, or other problems with muscle control or coordination. unusual paleness. Some side effects may occur that usually do not need medical attention.Yes each time Lamictal dose increased mildly 10 days later unsteady and stumbling when walking. Loss of appetite and weight. Epilepsy expert Dr Lu in Rochester NY gradually decreased Lamictal and gradually put on Topamax seizure med. Have remained on low dose of each for years seizure and problem free.Aug 29, 2023 · Long-Term Side Effects of Clonidine. There is the potential for a multitude of adverse effects involving the use of clonidine. People taking the substance may experience fever, headaches, fatigue, and general weakness. More serious effects on the cardiovascular system are also possible. These effects can include heart palpitations, congestive ... Precautions Talk with your doctor Lamictal (lamotrigine) is a brand-name drug that’s prescribed for bipolar disorder and epilepsy. As with other drugs, Lamictal can cause side effects....lamotrigine (Lamictal); lithium (Eskalith, Eskalith CR, Lithobid) ... The body can develop dependence if used long term. Side effects. Side effects of stimulants include: problems with sleep; poor ...Apr 8, 2021 · Although ophthalmological testing was performed in 1 controlled clinical trial, the testing was inadequate to exclude subtle effects or injury occurring after long-term exposure. Moreover, the capacity of available tests to detect potentially adverse consequences, if any, of lamotrigine's binding to melanin is unknown. Rarely, lurasidone can cause deadly symptoms. NMS can affect your heart, muscles, and kidneys. See your doctor right away if you get: A high fever. Stiff muscles. A change in your mood or behavior ...Sep 13, 2021 · For Healthcare Professionals General. The more commonly reported adverse reactions have included dizziness, headache, diplopia, ataxia, nausea,... Immunologic. In cases of hemophagocytic lymphohistiocytosis (HLH), patients have presented with signs of systemic... Hypersensitivity. Nervous system. ... At first I was just on abilify— a pretty high dose— and while it kept me free from hypomania, it didn’t really do much for the depression. Lamictal, on the other hand, has worked wonders in that respect. Very little side effects— I wake up nauseous but it fades after about an hour, and it’s definitely worth it.May 20, 2022 · Many people can take lamotrigine safely for several months or years. But there are some side effects that might happen over a long time. Long-term treatment with lamotrigine can cause osteoporosis and osteopenia, increasing your risk of breaking a bone. Your doctor can arrange for tests to check your bone strength. Descriptions. Lamotrigine is used alone or together with other medicines to help control certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it.Serious side effects; Other side effects; Professional info; FAQ; Applies to nystatin: oral suspension, oral tablet. Serious side effects of Nystatin. Along with its needed effects, nystatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Other side effects of ...Abdominal or stomach pain (severe) blurred vision, aching, burning, or swollen eyes. chest pain. confusion. discomfort while urinating or frequent urination. fever. hallucinations or seeing, hearing, or feeling things that are not there. itching. mental depression or other mood or mental changes.Precautions Talk with your doctor Lamictal (lamotrigine) is a brand-name drug that’s prescribed for bipolar disorder and epilepsy. As with other drugs, Lamictal can cause side effects....But Lamictal does give me low red blood cell counts, for which I take a B12 supplement. If Lamictal (or some other cause) has led to a B12 deficiency, that could explain a number of your symptoms. A B12 deficiency can cause: --weakness, tiredness or light-headedness. --rapid heartbeat and breathing.Apr 14, 2023 · 4. Narcotic painkillers . 5. Sleeping aids . 6. Incontinence drugs . 7. Antihistamines (first generation) How they can affect memory: Benzodiazepines dampen activity in key parts of the brain, including those involved in the transfer of events from short-term to long-term memory. Results. Treatment efficacy was observed at week 4, with the improved HSDS scores sustained until week 52 for all types of BP; 50% of the patients with any type of BP could be treated with LTG for 1 year, whereas ~40% could be treated for >1.5 years. However, 25% of the patients were withdrawn within the first 4 weeks.It’s used for long-term treatment of the more severe type of bipolar disorder, ... The more common side effects of Lamictal in people treated for bipolar I disorder include: nausea;In uncontrolled, long-term schizophrenia trials, this drug was associated with a mean increase in glucose from baseline of 1.8 mg/dL at 24 weeks, 0.8 mg/dL at 36 weeks, and 2.3 mg/dL at 52 weeks. Similar results were observed in bipolar depression studies.The most commonly observed side effects were dizziness, somnolence, diplopia, fatigue, nausea, vomiting, ataxia, abnormal vision, abdominal pain, tremor, dyspepsia, abnormal gait, headache, balance disorder, and asthenia. In clinical trials in children aged 1 month to 4 years, the most commonly reported side effect was somnolence.Sep 23, 2022 · Warning. Suicidality Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. b c d Venlafaxine is not approved for use in pediatric patients. 1 3 (See Pediatric Use under Cautions.) The long-term consequences of this are unknown. Lamotrigine is known to affect sleep. ... In addition, lamotrigine shares few side effects with other, unrelated ...Jan 10, 2023 · hoarseness. lack or loss of strength. pain in the lower back or side. swelling of the hands, feet, or lower legs. trembling or shaking. Common side effects that do require medical attention ... Traditional AEDs such as valproate and enzyme-inducing AEDs (EIAEDs) may produce high incidences of decreased libido. Recently, sexual function changes related to new AEDs have been reported. Topiramate, pregabalin and gabapentin may cause SD, whereas oxcarbazepine, lamotrigine and levetiracetam may improve sexual function.Lastly, we discuss the evidence on lithium's proposed suicide-preventive effects, the dangers of rapid discontinuation and lithium's adverse effects, particularly with regard to long-term treatment. Lithium has been the treatment of choice for patients with bipolar disorder (BD) for nearly 70 years.Serious side effects; Other side effects; Professional info; FAQ; Applies to nystatin: oral suspension, oral tablet. Serious side effects of Nystatin. Along with its needed effects, nystatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Other side effects of ...Took that to new provider and she explained for the first time that I was Bp2. I don't know that, that's lamictal. It takes about a week to hit your system and a bit longer to feel the full impacts, which should apply to dosages down too. I can normally get 3 or so days without it before I start to feel off.Aug 3, 2021 · Lamotrigine did not work in acute mania; it did not work in acute bipolar depression; and it did not work in rapid cycling. But bipolar disorder (BD) is a chronic condition, and that is where the medication succeeded: in the maintenance phase. The 2 positive studies looked at lamotrigine in the long term, over 1 and a half years. Aug 1, 2023 · Descriptions. Quetiapine is used alone or together with other medicines to treat bipolar disorder (depressive and manic episodes) and schizophrenia. Quetiapine extended-release tablet is also used together with other antidepressants to treat major depressive disorder. This medicine should not be used to treat behavioral problems in older adult ... Aug 3, 2021 · Lamotrigine did not work in acute mania; it did not work in acute bipolar depression; and it did not work in rapid cycling. But bipolar disorder (BD) is a chronic condition, and that is where the medication succeeded: in the maintenance phase. The 2 positive studies looked at lamotrigine in the long term, over 1 and a half years. Results. Treatment efficacy was observed at week 4, with the improved HSDS scores sustained until week 52 for all types of BP; 50% of the patients with any type of BP could be treated with LTG for 1 year, whereas ~40% could be treated for >1.5 years. However, 25% of the patients were withdrawn within the first 4 weeks.That said, the side effects associated with lamotrigine may be more tolerable than side effects induced by other anxiolytic medications. As was already mentioned, lamotrigine does not appear to impair cognitive function and may even provide a modest boost in cognition. Additionally, long-term trials suggest that lamotrigine is a “weight ...

Precautions Talk with your doctor Lamictal (lamotrigine) is a brand-name drug that’s prescribed for bipolar disorder and epilepsy. As with other drugs, Lamictal can cause side effects..... Free tile samples lowepercent27s

long term side effects of lamictal

In long-term studies of at least 48-weeks in adults, increased from baseline in mean fasting cholesterol, LDL, triglycerides were 5.6 mg/dL, 2.5 mg/dL, and 18.7 mg/dL, respectively. Mean increases in fasting lipid values (total cholesterol, LDL and triglycerides) were greater in patients without evidence of lipid dysregulation at baseline.Continue to take lamotrigine even if you feel well. Do not stop taking lamotrigine without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. Your doctor will probably decrease your dose gradually. If you suddenly stop taking lamotrigine, you may experience seizures.For Anxiety "I have taken lamotrigine for years with no side effects. It takes approximately 1.5-2 months for lamotrigine to take full effect. Side effects are typically avoided by starting at very low doses (I started at 25 mg once a day) and slowly increasing the dose over time.Abstract. Effective treatment of epilepsy depends on medication compliance across a lifetime, and studies indicate that drug tolerability is a significant limiting factor in medication maintenance. Available antiepileptic drugs (AEDs) have the potential to exert detrimental effects on cognitive function and therefore compromise patient wellbeing.Mar 11, 2023 · Common (1% to 10%): Arthralgia, blood creatinine phosphokinase increased/creatine phosphokinase increased, muscle rigidity, muscle spasms, muscle twitching, musculoskeletal stiffness, myalgia, pain in extremity. Uncommon (0.1% to 1%): Mobility decreased, muscle tightness, muscular weakness, musculoskeletal rigidity. Submitted by sportz_nut on Fri, 2009-05-01 - 16:46. I can't think of any long term for Lamictal, it has been my savior the past 8 years, as for Keppra, I don't know if it has and effect on the body, I do know that if your freind has trouble sleeping give them a Keppra, they should be out like a light. "My side effect from Keppra anyway". About lamotrigine Who can and cannot take it How and when to take it Side effects Pregnancy, breastfeeding and fertility Taking lamotrigine with other medicines and herbal supplements Common questions Lamotrigine can also cause other side effects. More common side effects. The more common side effects that can occur with use of lamotrigine include: dizziness; drowsiness; headache; double vision ...Results. Treatment efficacy was observed at week 4, with the improved HSDS scores sustained until week 52 for all types of BP; 50% of the patients with any type of BP could be treated with LTG for 1 year, whereas ~40% could be treated for >1.5 years. However, 25% of the patients were withdrawn within the first 4 weeks.Serious side effects; Other side effects; Professional info; FAQ; Applies to nystatin: oral suspension, oral tablet. Serious side effects of Nystatin. Along with its needed effects, nystatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Other side effects of ...Apr 8, 2021 · Although ophthalmological testing was performed in 1 controlled clinical trial, the testing was inadequate to exclude subtle effects or injury occurring after long-term exposure. Moreover, the capacity of available tests to detect potentially adverse consequences, if any, of lamotrigine's binding to melanin is unknown. Yes each time Lamictal dose increased mildly 10 days later unsteady and stumbling when walking. Loss of appetite and weight. Epilepsy expert Dr Lu in Rochester NY gradually decreased Lamictal and gradually put on Topamax seizure med. Have remained on low dose of each for years seizure and problem free.Rarely, lurasidone can cause deadly symptoms. NMS can affect your heart, muscles, and kidneys. See your doctor right away if you get: A high fever. Stiff muscles. A change in your mood or behavior ....

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